BRIEF INTRODUCTION
MSIsensor2 is an improved version of MSIsensor, featuring a large upgrade in the microsatellite instability (MSI) detection for tumor only or Cell-Free Tumor DNA (ctDNA) sequencing data.
Tumor Only vs Paired
Correlation coefficient between the two modules is 0.94, that levels of the msi score of different samples perform similarly under the two modules.
High Discrimination Ability
The test results of TCGA and EGA showed the comparable performance advantage of tumor only module over original MSIsensor tumor/normal paired module. In addition, the results of our tests based on ctDNA sequencing data with tumor only model showed an outstanding discrimination ability on microstatellite status.
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